We are trying to understand why Crohn’s and Colitis behaves differently in each person and why certain treatments are effective for some people but not others. To do this we need to collect data from a large number of people with Crohn’s and Colitis, starting before they are diagnosed and have not received treatment. This study involves collecting information and samples from people who have symptoms that mean they might have Crohn’s or Colitis:
Up front tests
● We will collect a stool sample, blood sample and you will complete some questionnaires about your lifestyle, diet and the impact of your symptoms.
● We will take additional biopsy samples during your diagnostic colonoscopy (an exploration of the bowel with a flexible camera) that you will have as part of your standard hospital care.
If you are not diagnosed with Crohn’s or Colitis
● No further research visits are needed, but we would like to access your medical records later on to collect information on any Crohn’s or Colitis-related symptoms or conditions you may subsequently develop.
● You will continue to be seen by the hospital for any NHS tests or follow up you need.
If you are diagnosed with Crohn’s or Colitis
● We will collect stool samples and blood samples every three months for the first year and you will be given health questionnaires to complete.
● We will repeat the above every six months for the second year.
● You will have a follow up colonoscopy after one year to check on the health of your bowel.
Taking part in the study will not impact the treatment you receive, however if you are diagnosed with Crohn’s or Colitis you may have access to more frequent check-ups and enhanced access to your dedicated Crohn’s and Colitis team than if you didn’t take part.
How much time does it take to be involved?
Each study visit will take approximately 30 minutes. Wherever possible these visits will be done on the same day as your routine trips to the hospital to minimise inconvenience.
Other study activities, such as collection of a stool sample and completion of some questionnaires can take place at home in your own time. Visits involving a colonoscopy procedure are likely to take longer.
